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One of the most well-known yet least understood aspects of the 1918 influenza pandemic is the disproportionately high mortality among young adults. Contemporary accounts further describe the victims as healthy young adults, which is contrary to the understanding of selective mortality, which posits that individuals with the highest frailty within a group are at the greatest risk of death. We use a bioarchaeological approach, combining individual-level information on health and stress gleaned from the skeletal remains of individuals who died in 1918 to determine whether healthy individuals were dying during the 1918 pandemic or whether underlying frailty contributed to an increased risk of mortality. Skeletal data on tibial periosteal new bone formation were obtained from 369 individuals from the Hamann–Todd documented osteological collection in Cleveland, Ohio. Skeletal data were analyzed alongside known age at death using Kaplan–Meier survival and Cox proportional hazards analysis. The results suggest that frail or unhealthy individuals were more likely to die during the pandemic than those who were not frail. During the flu, the estimated hazards for individuals with periosteal lesions that were active at the time of death were over two times higher compared to the control group. The results contradict prior assumptions about selective mortality during the 1918 influenza pandemic. Even among young adults, not everyone was equally likely to die—those with evidence of systemic stress suffered greater mortality. These findings provide time depth to our understanding of how variation in life experiences can impact morbidity and mortality even during a pandemic caused by a novel pathogen. 

Amid global challenges like climate change, extinctions, and disease epidemics, science and society require nuanced, international solutions that are grounded in robust, interdisciplinary perspectives and datasets that span deep time. Natural history collections, from modern biological specimens to the archaeological and fossil records, are crucial tools for understanding cultural and biological processes that shape our modern world. At the same time, natural history collections in low and middle-income countries are at-risk and underresourced, imperiling efforts to build the infrastructure and scientific capacity necessary to tackle critical challenges. The case of Mongolia exemplifies the unique challenges of preserving natural history collections in a country with limited financial resources under the thumb of scientific colonialism. Specifically, the lack of biorepository infrastructure throughout Mongolia stymies efforts to study or respond to large-scale environmental changes of the modern era. Investment in museum capacity and training to develop locally-accessible collections that characterize natural communities over time and space must be a key priority for a future where understanding climate scenarios, predicting, and responding to zoonotic disease, making informed conservation choices, or adapting to agricultural challenges, will be all but impossible without relevant and accessible collections. 

Yersinia pestis, the bacterium responsible for at least three pandemics in the past, is still a threat to modern populations. The bacterium has potential to evolve rapidly and persists in natural animal reservoirs around the globe. Epidemic diseases such as plague can dramatically alter and shape human demography, biology, and socio-cultural practices. Through the synthesis of biomolecular analyses with bioarchaeological data, researchers have begun to uncover the effects of past epidemics on modern populations and are also searching for the origins of the Y. pestis bacterium. Understanding the origins, behaviors, and consequences of diseases with epidemic potential in the past can contribute to ongoing discourse in public health, social policy, economy, and biology, as well as inspire positive changes in living populations. We review here recent literature on Y. pestis ecology and evidence of the bacteria’s evolution in prehistory before discussing ongoing research at the Hamin Neolithic settlement site that is suspected to have collapsed from an epidemic disease. 

The ongoing COVID-19 pandemic has justifiably captured the attention of people around the world since late 2019. It has produced in many people a new perspective on or, indeed, a new realization about our potential vulnerability to emerging infectious diseases. However, our species has experienced numerous catastrophic disease pandemics in the past, and in addition to concerns about the harm being produced during the pandemic and the potential long-term sequelae of the disease, what has been frustrating for many public health experts, anthropologists, and historians is awareness that many of the outcomes of COVID-19 are not inevitable and might have been preventable had we actually heeded lessons from the past. We are currently witnessing variation in exposure risk, symptoms, and mortality from COVID-19, but these patterns are not surprising given what we know about past pandemics. We review here the literature on the demographic and evolutionary consequences of the Second Pandemic of Plague (ca. fourteenth–nineteenth centuries C.E.) and the 1918 influenza pandemic, two of the most devastating pandemics in recorded human history. These both provide case studies of the ways in which sociocultural and environmental contexts shape the experiences and outcomes of pandemic disease. Many of the factors at work during these past pandemics continue to be reproduced in modern contexts, and ultimately our hope is that by highlighting the outcomes that are at least theoretically preventable, we can leverage our knowledge about past experiences to prepare for and respond to disease today.